The Scientist Behind 3X4

Dr. Yael Joffe PhD

Founder and Chief Science Officer

In 2018, Dr. Yael Joffe founded 3X4 Genetics and now serves as its Chief Science Officer. Yael brings over 20 years of experience in nutrition, genetics, sound research, clinical practice and scientific integrity to 3X4.

... Yael is globally acknowledged as a leading expert in the field of nutrigenomics. In 2000, she was part of the team that built the first lifestyle genetics test, and since then has been responsible for the building of many others. She is the author of four books, The Power of Genetics, It’s Not Just Your Genes, Genes to Plate, and SNP Journal. Yael has been published in multiple peer-reviewed scientific journals, hosts the Power of Genetics podcast, and is a highly regarded speaker in genetics.

Yael built the first online nutrigenomics platform for clinician education and has developed and supervised genomics courses around the world. She has trained thousands of healthcare practitioners globally, also teaching at Rutgers University and the Maryland University of Integrative Health.

Yael is globally acknowledged as a leading expert in the field of nutrigenomics. In 2000, she was part of the team that built the first lifestyle genetics test, and since then has been responsible for the building of many others. She is the author of four books, The Power of Genetics, It’s Not Just Your Genes, Genes to Plate, and SNP Journal. Yael has been published in multiple peer-reviewed scientific journals, hosts the Power of Genetics podcast, and is a highly regarded speaker in genetics.

Yael built the first online nutrigenomics platform for clinician education and has developed and supervised genomics courses around the world. She has trained thousands of healthcare practitioners globally, also teaching at Rutgers University and the Maryland University of Integrative Health.

Our Scientific Approach Is Based On 3 Key Principles

Systems Approach

Our bodies are complex. 3X4 looks at how our genes work together in cellular pathways and functional systems to control processes such as inflammation, metabolism, and detoxification.

Going Upstream

Traditionally, we have spent far too much time focusing on trying to fix symptoms. At 3X4, we want to change this by understanding what’s happening at a deep cellular level so we can prevent, delay, or reverse disease.

Sustainable Change

We believe that health is not a static condition, but a daily choice. Using our Blueprint and the guidance of an expert practitioner you can gain a deeper understanding of your body and the daily choices you need to make.

It’s Not About Patching Symptoms, It’s About Understanding The Root Cause

Your genes don’t work in isolation – they work with each other and the body’s environment. What we eat, how we move, our stress levels, and our emotional lives affect how our genes behave. Understanding our individual genetic blueprint can guide us to make health choices that help us to live happier, longer, and better.

The science behind 3X4 is based on extensive research, combined with clinical practice to ensure that every recommendation we make is both scientifically accurate and proven to work in clinical practice.

Meet Our Advisors

Dr. Jeffrey BlandPhD, FACN, FACB, CNS

Jeff is arguably a pioneer of modern medicine, defining functional medicine as we know it today. For over 35 years, he has guided the evolution of functional nutrition and medicine, authored 11 books on the subject and is the principal author of over 120 peer-reviewed scientific articles. Jeff has been the CEO of HealthComm International, the Chief Science Officer for Metagenics, as well as the president of MetaProteomics where he led a team of over 100 research scientists. But one of his greatest contributions is his deep understanding of the intersection between healthcare practitioners and the consumer. This is reflected in his current work, the Professional Lifestyle Medicine Institute, which furthers the education of practitioners, and his new startup, bringing Big Bold Health to healthcare conscious consumers globally.

Dr. Myles SparMD, MPH

Myles is considered to be the foremost expert in Men’s Health in the USA, working as a consultant to the NBA and many top-performing athletes. In his earlier life, Myles worked as a humanitarian doctor for Medecins sans Frontieres/Doctors without Borders, which triggered his appreciation for the role of health in each person’s ability to achieve their goals. This intrinsic drive to uplift the health of the underserved led Myles to receive the Bravewell Award for Leadership in Integrative Medicine in 2013. He directs the Integrative Medicine program at the Men’s Health Foundation in Los Angeles and at the Simms-Mann Health and Wellness Center at Venice Family Clinic. He is also the author of "Integrative Men’s Health", and his most recent book, "Optimal Men’s Health".

Dr. Christine HoughtonPhD, BSc, R.Nutr

Christine holds a PhD in Nutrigenomics and a BSc in Biochemistry from the University of Queensland, Australia. She is a registered Nutritionist as well as an Adjunct Lecturer at the University of Queensland. After practicing nutritional medicine for 3 decades, Christine focused on utilising her extensive clinical experience to research, develop, and teach other clinicians. In addition to her scientific and lay publications, she authored “Switched On – Harnessing the Power of Nutrigenomics to Optimise Health”, and is the co-author of two courses in nutrigenomics for practicing clinicians.

Kathie SwiftMS, RDN, LDN, FAND, EBQ

Author, educator, and clinical nutritionist, Kathie integrates the best of nutritional science and mind body modalities. Kathie graduated from Arizona State University with a Master of Science in Nutrition and expanded her conventional dietetics background with extensive training in functional medicine. She is the co-founder of the Integrative and Functional Nutrition Academy, an online functional nutrition training program for healthcare professionals. Kathie also directs the Center for Mind Body Medicine’s highly acclaimed Food as Medicine program. She pioneered innovative functional nutrition programs at Canyon Ranch Health Resorts, Kripalu Center for Yoga and Health, and The UltraWellness Center, and continues to consult at all three organizations today. Besides being the author of two books on digestive health, Kathie is a contributing author for numerous medical textbooks as well as a scientific reviewer for "Integrative Medicine: A Clinician’s Journal" and "Military Medicine Journal".

Dr. Ruth DeBuskPhD, MS, RDN

Ruth is unique in that she has had extensive training and experience in both nutrition and dietetics, and in genomics and molecular biology. Her career has included being a genetics professor and researcher, practitioner in clinical nutrition and genomics, and a developer of small businesses within the biotech industry. Throughout, she has remained committed to training healthcare professionals and their patients about how daily lifestyle choices influence gene expression and how to learn to make choices that are more appropriate for their personal genetic makeup in order to live a healthy, joyful life. Ruth authored “Genetics: The Nutrition Connection” and co-authored “It’s Not Just Your Genes” with Dr. Yael Joffe. She has also published on nutrigenomics in peer-reviewed journals.